Liver Cancer

Scientific Documents
Targeting PKLR and lipogenic enzymes through JNK inhibition to develop a therapeutic strategy for MASLD and MASH
Scientific Documents
Phospho-JNK agonists show promising effects for the treatment of hepatocellular carcinoma
Scientific Documents
Targeting PKLR in Liver Diseases
Scientific Documents
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose induced metabolic dysfunction in rats
Scientific Documents
Synthesis of novel tetrahydrobenzo[b]thiophene-3-carbonitrile (THBTC)-based heterocycles: Structural insights, reactivity profiles, and in-silico bioactivity studies
Patents
Small Molecule Treatment of Fatty Liver Disease and HCC -PCT
Patents
Small Molecule Treatment of Fatty Liver Disease and HCC - EPO
Scientific Documents
Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins
Scientific Documents
Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma
Scientific Documents
Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene-1-sulfonamide derivatives
Presantations
Tailoring Liver Pyruvate Kinase Inhibitors via Structural Guided Optimization
Scientific Documents
Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase
Scientific Documents
Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase
Scientific Documents
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning