Karaciğer Kanseri

Bilimsel Yayınlar
Targeting PKLR and lipogenic enzymes through JNK inhibition to develop a therapeutic strategy for MASLD and MASH
Bilimsel Yayınlar
Phospho-JNK agonists show promising effects for the treatment of hepatocellular carcinoma
Bilimsel Yayınlar
Targeting PKLR in Liver Diseases
Bilimsel Yayınlar
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose induced metabolic dysfunction in rats
Bilimsel Yayınlar
Synthesis of novel tetrahydrobenzo[b]thiophene-3-carbonitrile (THBTC)-based heterocycles: Structural insights, reactivity profiles, and in-silico bioactivity studies
Patentler
Small Molecule Treatment of Fatty Liver Disease and HCC -PCT
Patentler
Small Molecule Treatment of Fatty Liver Disease and HCC - EPO
Bilimsel Yayınlar
Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins
Bilimsel Yayınlar
Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma
Bilimsel Yayınlar
Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene-1-sulfonamide derivatives
Sunumlar
Tailoring Liver Pyruvate Kinase Inhibitors via Structural Guided Optimization
Bilimsel Yayınlar
Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase
Bilimsel Yayınlar
Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase
Bilimsel Yayınlar
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning